Ubiquitin Proteasome
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 17 genes have a known function matching the annotation |
Why this annotation
No single dominant pathway emerges. UBLCP1 and UBE2V2 point to ubiquitin-proteasome regulation; PDCD10 is a STRIPAK complex member involved in apoptosis; MORC3 is a chromatin/antiviral ATPase; ARPC1A is Arp2/3 actin complex; P4HA1 is prolyl hydroxylase; TMEM30A is a phospholipid flippase subunit. All genes show weak membership and uniform expression. The module is poorly coherent and mixed. The best unifying theme across the most genes is ubiquitin/proteasome-related housekeeping, but certainty is low. Neighbor modules M42 and M101 share cytoskeletal (ARPC1A) and ER/proteostasis overlap, suggesting this module captures residual housekeeping co-variation.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.85
- Monocyte Chemotaxis · correlation 0.84
- Actin Cytoskeleton · correlation 0.84
- Vesicular Immune Signaling · correlation 0.81
- Transcriptional Regulation · correlation 0.80
- Transcription & Splicing · correlation 0.80
- Cell Cycle Regulation · correlation 0.79
- M18 · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.