ER-Golgi Trafficking
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression, indicating a poorly defined mixed module. Hub genes span multiple housekeeping programs: vesicular/ER-Golgi trafficking (COPE, TMED9, SFT2D1, LMAN2), protein quality control/ubiquitin (UBE2I, STUB1, FKBP1A), mitochondrial metabolism (SUCLG1, NDUFS3, MCUR1, GLRX5), and cytoskeletal dynamics (TWF2, STMN1, CALM2). The co-expression with M16 in the network likely reflects shared constitutive cellular maintenance activity. The strongest sub-theme is ER-Golgi vesicular trafficking.
Genes
Most correlated modules
- ER-Golgi Trafficking · correlation 0.92
- Lysosomal mTOR Signaling · correlation 0.85
- Mitochondrial Assembly · correlation 0.85
- Metabolic Housekeeping · correlation 0.84
- Clathrin-mediated Endocytosis · correlation 0.84
- Actin Cytoskeleton · correlation 0.84
- General Cellular Maintenance · correlation 0.83
- General Housekeeping · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.