Clathrin-mediated Endocytosis
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 20 genes have a known function matching the annotation |
Why this annotation
ARPC5 is an Arp2/3 complex subunit driving actin nucleation/branching; CLTA is clathrin light chain A involved in clathrin-mediated endocytosis; AP1S2 is an AP-1 adaptor subunit for vesicle budding from TGN/endosomes; KDELR2 is an ER retention receptor (KDEL receptor 2); PRDX3 is a mitochondrial peroxiredoxin; NDUFV2 is a complex I subunit; MRPL16 is a mitochondrial ribosomal protein; TMBIM4 regulates ER calcium and anti-apoptosis; YWHAB is a 14-3-3 scaffold protein. The module mixes vesicular trafficking (clathrin/AP-1), cytoskeletal (Arp2/3), and mitochondrial elements — a weakly coherent housekeeping module. The clathrin/adaptor protein theme is the most represented.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
- Actin Cytoskeleton · correlation 0.91
- Fc Receptor Trafficking · correlation 0.90
- ER Redox Homeostasis · correlation 0.87
- Lysosomal mTOR Signaling · correlation 0.87
- ER Protein Folding · correlation 0.87
- ER Protein Folding · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.