Centrosome Organization
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub genes NIN (ninein, centrosome/microtubule anchoring), NUMA1 (nuclear mitotic apparatus, spindle pole organization), and ABI1 (Abl-interactor, actin polymerization at centrosome) point to centrosome and cytoskeletal organization. MDN1 is a large AAA-ATPase involved in ribosome biogenesis. ZNF148 is a transcription factor. OXR1 is an oxidative stress resistance gene. SPG11 links to autophagy. The module is weakly coherent and mixed, but the centrosome/cytoskeletal thread (NIN, NUMA1, ABI1) is the strongest identifiable program. Neighbor context of similarly weak housekeeping modules supports a broad structural/housekeeping interpretation.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.90
- Chromatin & Ubiquitin · correlation 0.87
- DNA Repair Housekeeping · correlation 0.87
- Lipid Transport & Membrane · correlation 0.87
- pDC Identity Signaling · correlation 0.85
- Polycomb Transcription · correlation 0.84
- Mixed Regulatory Background · correlation 0.83
- DNA Damage Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.