Chromatin Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include MED14 (Mediator transcription complex subunit), DCAF1 and DCAF6 (DDB1-CUL4 associated factors, ubiquitin E3 ligase substrate receptors), HMG20A (chromatin remodeling), QSER1 (epigenetic regulator, DNA methylation maintenance), NCOA6 (nuclear receptor coactivator), DDX10 (RNA helicase, ribosome biogenesis), BMP2K (kinase). The module has a loose chromatin/transcription regulation theme but is too heterogeneous for a specific label. Neighbor modules M166/M167 also show mixed housekeeping, consistent with a background co-expression neighborhood.
Genes
Most correlated modules
- Mixed Housekeeping · correlation 0.91
- Mixed Housekeeping · correlation 0.90
- Mixed Housekeeping · correlation 0.90
- Low-coherence Background · correlation 0.79
- Epigenetic Regulation · correlation 0.79
- Epigenetic Regulation · correlation 0.78
- CX3CR1 Migration · correlation 0.76
- Low-coherence Background · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.