Low-coherence Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 13 of 22 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. The gene set includes PPP3CA (calcineurin/calcium signaling), FYN (Src-family kinase/TCR signaling), NEK7 (NLRP3 inflammasome activation/mitosis), PIP4K2A (phosphoinositide kinase), MTM1 (myotubularin phosphatase), IQGAP2 (scaffold/cytoskeleton), ARHGAP12 (Rho GAP), RAP1GDS1 (GEF for RAP1/RAS), TLK1 (tousled-like kinase/chromatin), ELP4 (elongator complex/transcription), BICD1 (dynein adaptor/vesicle), LSM14A (RNA processing/P-bodies), CPPED1 (phosphatase), EPDR1 (ependymin-related), KCNC3 (potassium channel), COG1 (Golgi/vesicle), CCSER1 (serine-rich), ADPRS (ADP-ribosylhydrolase), R3HDM1 (RNA binding), PRH1 (proline-rich protein). The module is highly heterogeneous with signaling, cytoskeletal, RNA processing, and Golgi genes. No single program dominates; low-coherence background module.
Genes
Most correlated modules
- Low-coherence Background · correlation 0.92
- Low-coherence Background · correlation 0.91
- Low-coherence Background · correlation 0.88
- Low-coherence Background · correlation 0.87
- Low-coherence Background · correlation 0.83
- Cilia & Centrosome · correlation 0.83
- Intracellular Kinase Signaling · correlation 0.82
- Mixed Housekeeping · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.