Stress Kinase Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 23 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Notable genes: IFT88 (intraflagellar transport 88, ciliogenesis), TRAF6 (TNF receptor-associated factor 6, NF-kB/TLR signaling), SMURF1 (SMAD ubiquitin regulatory factor 1, TGF-beta/BMP pathway), SIAH1 (E3 ubiquitin ligase, p53/hypoxia), MAP3K4 (MEKK4, stress-activated MAPK), STK39 (SPAK kinase, osmotic stress), MTFR1 (mitochondrial fission regulator), TRAK2 (mitochondrial trafficking), FOXN3 (transcription factor), TBX19 (T-box transcription factor, pituitary). The module is highly heterogeneous. IFT88 is a strong ciliogenesis marker; TRAF6 links to innate immune signaling; SMURF1 to TGF-beta. No single coherent program. The loosest theme might be stress-responsive kinase/ubiquitin signaling, but this is a weak catch-all module.
Genes
Most correlated modules
- Kinase Phosphatase Signaling · correlation 0.92
- Mixed Regulatory Background · correlation 0.82
- Intracellular Kinase Signaling · correlation 0.80
- Mixed Regulatory Background · correlation 0.79
- Low-coherence Background · correlation 0.77
- DNA Damage Response · correlation 0.72
- Low-coherence Background · correlation 0.71
- Autophagy & Proteostasis · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.