Autophagy Cytoskeletal
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes include FMNL1 (formin-like actin nucleator), GABARAPL1 (autophagy receptor/LC3 family), PLAUR (urokinase receptor, migration/invasion), SOX4 (developmental transcription factor), RGS13 (G-protein signaling regulator in B cells/pDCs), KPNA2 (importin-alpha, nuclear transport), DDX21 (RNA helicase, ribosome biogenesis). The autophagy gene GABARAPL1 and cytoskeletal FMNL1 are notable, but all genes show weak membership. The module loosely reflects autophagy and cytoskeletal dynamics but is poorly coherent.
Genes
Most correlated modules
- TGF-beta Survival · correlation 0.92
- Chemokine Migration Response · correlation 0.90
- pDC Activation Response · correlation 0.89
- RNA Processing · correlation 0.86
- Transcriptional Repression · correlation 0.86
- Transcriptional Regulation · correlation 0.84
- Glucocorticoid Stress Response · correlation 0.83
- Glucocorticoid Receptor · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.