Glycolytic Metabolism
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes TPI1 and GAPDH are core glycolytic enzymes; IMPDH2 supports nucleotide biosynthesis; PRDX1 is a redox enzyme. These suggest a metabolic/housekeeping program. However, CD63 (lysosomal/vesicular), ANXA2 (membrane scaffold), S100A10 (calcium), APOL6 (innate immunity), PTGS1 (COX-1 prostaglandin synthesis), and CST7 (cystatin, cytotoxic cell marker) are functionally diverse. All genes show weak membership, indicating a mixed module. The glycolytic genes are the most coherent sub-group.
Genes
Most correlated modules
- Myeloid Differentiation · correlation 0.86
- Progenitor Transcription · correlation 0.83
- Survival & Adhesion · correlation 0.71
- Hematopoietic Development · correlation 0.66
- Post-transcriptional Regulation · correlation 0.61
- Lipid Metabolic Reprogramming · correlation 0.61
- Oxidative Stress Response · correlation 0.60
- Innate Myeloid Effector · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.