General Cellular Maintenance
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
NDUFS2 is a core complex I subunit; LDHB encodes lactate dehydrogenase B (glycolysis/NAD+ regeneration); RHOA is a Rho GTPase regulating actin cytoskeleton; BAX is a pro-apoptotic BCL-2 family member; PEBP1 inhibits Raf kinase; PPP4C is a serine/threonine phosphatase; UBE2D2 is a ubiquitin-conjugating enzyme; PIN1 is a prolyl isomerase; KIF17 is a kinesin motor. No single pathway dominates — this is a highly mixed, weakly coherent housekeeping module. The presence of BAX and PEBP1 hints at apoptosis regulation but is insufficient to define the module. Uniform expression and all-weak membership confirm low specificity.
Genes
Most correlated modules
- Lysosomal mTOR Signaling · correlation 0.92
- Actin Cytoskeleton · correlation 0.90
- ER-Golgi Trafficking · correlation 0.88
- Mitochondrial Assembly · correlation 0.88
- Metabolic Housekeeping · correlation 0.85
- Actin Cytoskeleton · correlation 0.85
- Actin Cytoskeletal Remodeling · correlation 0.84
- ER-Golgi Trafficking · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.