COPI Vesicle Trafficking
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Weak, mixed module enriched in plasmablasts. Hub genes include SRSF4/LSM14A/EWSR1 (RNA processing), COPA/ARCN1/ARF6 (COPI vesicle trafficking), DDB1 (ubiquitin/DNA damage), and SQLE (cholesterol biosynthesis). No single tight program dominates, consistent with weak coherence. The RNA processing and vesicle trafficking components likely reflect the high secretory and RNA metabolism demands of plasmablasts. COPI coat genes COPA/ARCN1 and ARF6 form a coherent vesicle trafficking sub-cluster.
Genes
Most correlated modules
- Nuclear Export Replication · correlation 0.95
- Plasmablast Stress Activation · correlation 0.94
- Plasmablast Proliferation · correlation 0.94
- Nuclear Transport Chromatin · correlation 0.93
- Plasma Cell Differentiation · correlation 0.93
- Plasmablast Apoptosis · correlation 0.93
- Polyamine Biosynthesis · correlation 0.93
- Plasmablast Differentiation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.