Ribosome Biogenesis
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
The module is dominated by genes involved in ribosome biogenesis and nucleolar function: FBL (fibrillarin, rRNA 2'-O-methylation), TSR1 (pre-40S ribosome biogenesis factor), C12orf75 (nucleolar, 19.8x plasmablast enrichment), RUVBL1 (AAA+ ATPase involved in ribosome assembly and chromatin remodeling), CCT2 (TRiC chaperonin supporting ribosome assembly). Additional genes include HDAC2 (chromatin), POLE3 (DNA replication), PAICS (purine biosynthesis supporting nucleotide supply), DDX1 (RNA helicase), SSB (La protein, RNA processing), HNRNPAB (hnRNP). Many weak members reflect a loosely coordinated nucleolar/proliferative program. Neighbor context (M78 OxPhos, M45 chaperonin) supports a plasmablast proliferation/biosynthesis network.
Genes
Most correlated modules
- Chaperonin Protein Folding · correlation 0.97
- RNA Splicing & Glycolysis · correlation 0.96
- Oxidative Stress Response · correlation 0.96
- Housekeeping Mixed · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
- Spliceosome snRNP Assembly · correlation 0.95
- RNA Splicing Processing · correlation 0.94
- S-phase DNA Replication · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.