Spliceosome snRNP Assembly
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
The module is anchored by core spliceosomal Sm proteins: SNRPF, SNRPD1, SNRPE, SNRPG (all SmB/D/E/F/G components of the heptameric Sm ring that assembles on snRNAs). LSM2, LSM3, LSM5 are LSm proteins involved in U6 snRNA stabilization and mRNA decay. Together these define a tight spliceosome/snRNP assembly program. ANP32B (chromatin/RNA processing), RANBP1 (nuclear transport of snRNPs), and CCT6A (chaperonin for snRNP assembly) support this. RPA3 (DNA replication protein A) and HMGN1 (chromatin) are peripheral. NDUFA6 is a lone OxPhos gene likely co-regulated due to plasmablast metabolic demand. The module is strongly coherent and the snRNP identity is unambiguous. Neighbor M32 contains LSM4, confirming LSm protein co-expression across this neighborhood.
Genes
Most correlated modules
- RNA Splicing & Glycolysis · correlation 0.98
- Proteasome Activity · correlation 0.98
- hnRNP RNA Processing · correlation 0.98
- Glycolytic Reprogramming · correlation 0.97
- Mitochondrial Respiration · correlation 0.97
- Ribosome Biogenesis · correlation 0.97
- Chaperonin Protein Folding · correlation 0.97
- Protein Quality Control · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.