N-glycosylation ER
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module enriched in plasmablasts. Hub genes STT3A (catalytic subunit of oligosaccharyltransferase complex, N-glycosylation), RPN1 (ribophorin I, OST complex subunit), GPAA1 (GPI transamidase, GPI anchor attachment), GMPPB (GDP-mannose pyrophosphorylase, mannose donor synthesis), SEC61A1 (ER translocon, protein import into ER), EIF4G2 (translation initiation). This module centers on co-translational N-glycosylation and GPI anchor biosynthesis in the ER, critical for antibody glycosylation. CLTC (clathrin) and IFI27L1 are peripheral. Neighbors M36 and M51 share the secretory pathway theme; M47 specifically captures glycosylation machinery.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.96
- ER Secretory Expansion · correlation 0.95
- Nuclear Export Replication · correlation 0.94
- Polyamine Biosynthesis · correlation 0.93
- COPI Vesicle Trafficking · correlation 0.91
- ER-Golgi Secretory Pathway · correlation 0.91
- Unfolded Protein Response · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.