ER Protein Folding
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module strongly enriched in plasmablasts. Hub genes HSP90B1 (GRP94), CANX (calnexin), CALR (calreticulin), PDIA4, DNAJB11, SDF2L1, LMAN1, MLEC are all canonical ER chaperones and lectins involved in protein folding quality control and the unfolded protein response. SSR1 (signal sequence receptor) and VCP (ERAD) further support ER protein processing. This is a classic ER proteostasis/UPR module characteristic of antibody-secreting plasma cells under high secretory load. Neighbors M51 and M47 share the secretory pathway theme, with M36 representing the ER folding hub.
Genes
Most correlated modules
- N-glycosylation ER · correlation 0.96
- Plasmablast Stress Activation · correlation 0.94
- ER Secretory Expansion · correlation 0.94
- ER-Golgi Secretory Pathway · correlation 0.94
- Nuclear Export Replication · correlation 0.93
- Plasmablast Proliferation · correlation 0.92
- Unfolded Protein Response · correlation 0.92
- COPI Vesicle Trafficking · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.