ER-Golgi Secretory Pathway
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module enriched in plasmablasts. Hub genes SEC63 (ER translocon accessory), SRPRA/SRPRB (signal recognition particle receptor alpha/beta, co-translational targeting to ER), TMED5 (p24 family COPI/COPII cargo receptor), SURF4 (ERGIC cargo receptor), KTN1 (kinectin, ER-Golgi tethering), ACBD3 (Golgi integrity), CALU (calumenin, ER lumen Ca2+-binding), MAN1A1 (Golgi alpha-mannosidase I, N-glycan trimming), CLINT1 (clathrin adaptor). Together these define ER targeting, translocon function, and ER-to-Golgi vesicular transport — the secretory pathway upstream of antibody secretion. Complements M36 (ER folding) and M47 (N-glycosylation).
Genes
Most correlated modules
- ER Protein Folding · correlation 0.94
- ER Secretory Expansion · correlation 0.92
- Unfolded Protein Response · correlation 0.91
- N-glycosylation ER · correlation 0.91
- COPI Vesicle Trafficking · correlation 0.91
- Plasmablast Differentiation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.