Mixed OxPhos Secretory
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
All genes are enriched in pre_tuft cells (~2.4-3.6x), except PIGR which shows 14.7x enrichment in pre_tuft. Hub genes include RNASET2 (ribonuclease T2, lysosomal RNA degradation), UQCRC1 (ubiquinol-cytochrome c reductase core protein 1, Complex III), BSG (basigin/CD147, glycoprotein involved in lactate transport and matrix metalloproteinase induction), PYCARD (ASC/TMS1, inflammasome adaptor), SMIM15, ARF1 (ADP-ribosylation factor 1, vesicle trafficking), EEF2 (eukaryotic translation elongation factor 2), NDUFC2 (Complex I subunit), HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0), TMEM59 (lysosomal membrane protein), RAC1 (Rho GTPase, cytoskeletal dynamics), PIGR (polymeric immunoglobulin receptor, IgA/IgM transcytosis - extremely enriched). The module is mixed: mitochondrial OxPhos (UQCRC1, NDUFC2), vesicle/lysosomal trafficking (RNASET2, ARF1, TMEM59), and PIGR as a notable outlier suggesting some secretory/immune function. The dominant neighbor context is OxPhos/pre-tuft, but PIGR and PYCARD introduce an inflammatory/secretory flavor.
Genes
Most correlated modules
- ATP Synthase OxPhos · correlation 0.97
- Mitochondrial OxPhos Complex I · correlation 0.97
- Pre-tuft Mitochondrial Metabolic · correlation 0.96
- Pre-tuft Progenitor Metabolism · correlation 0.95
- ER Vesicle Trafficking · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.94
- Respiratory Chain OxPhos · correlation 0.94
- ER Membrane Biogenesis · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.