Iron Homeostasis Housekeeping
Gene co-expression module in Tuft cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes FTL and FTH1 are ferritin subunits involved in iron storage and oxidative stress response. ACTB, ACTG1, TMSB4X, TMSB10 are cytoskeletal/actin-binding proteins. EEF1A1 is a translation elongation factor. B2M is MHC class I beta-2 microglobulin. CST3 is cystatin C (lysosomal cysteine protease inhibitor). TPT1 (TCTP) is a calcium-binding housekeeping protein. S100A6 is a calcium-binding protein. Many genes show uniform expression across subsets, high mean expression (8.677) and high detection rate (75.5%), consistent with housekeeping functions. The iron storage (FTL/FTH1) and cytoskeletal components dominate. Inflammation effects are not significant. This module represents constitutive housekeeping functions with iron homeostasis as the distinguishing feature.
Genes
Most correlated modules
- OxPhos Pre-tuft · correlation 0.81
- Oxidative Stress Response · correlation 0.78
- Nucleolar RNA Processing · correlation 0.77
- Electron Transport Chain · correlation 0.77
- Mitochondrial Proteostasis · correlation 0.76
- Pre-tuft Metabolic Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.