Pre-tuft Metabolic Identity
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
This module contains multiple mitochondrial OxPhos genes (ETFB - electron transfer flavoprotein beta, ATP5PB - ATP synthase peripheral stalk, UQCRFS1 - Complex III Rieske subunit, CHCHD10 - mitochondrial intermembrane space, CISD3 - mitochondrial iron-sulfur), proteasome subunits (PSMA7, PSMB1), spliceosomal snRNPs (SNRPE, SNRPF), ER components (SEC61G, PPIB/cyclophilin B), and the highly enriched LEFTY1 (TGF-beta superfamily member, 40x in pre_tuft). EIF3K contributes to translation. The module is suppressed in UC inflammation and restored by CD treatment. The dominant theme across hub genes is mitochondrial electron transport and protein processing, with LEFTY1 as a notable pre_tuft marker. This is a mixed housekeeping/metabolic module characteristic of pre_tuft progenitor identity.
Genes
Most correlated modules
- Mitochondrial Proteostasis · correlation 0.98
- Sulfur Redox Detox · correlation 0.98
- Respiratory Chain Complex I · correlation 0.97
- Mitochondrial OxPhos/TCA · correlation 0.97
- Nucleolar RNA Processing · correlation 0.97
- Intestinal Progenitor Differentiation · correlation 0.96
- OxPhos Pre-tuft · correlation 0.95
- Oxidative Stress Response · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.