Oxidative Stress Response
Gene co-expression module in Tuft cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
YWHAB (14-3-3β) is a scaffold protein regulating apoptosis, cell cycle, and stress signaling. PRDX1 is a peroxiredoxin antioxidant enzyme. PSME1 (PA28α) is a proteasome activator involved in antigen processing and oxidative stress response. IFITM3 is an interferon-induced transmembrane protein with antiviral and stress functions. DEK is a chromatin-associated oncoprotein. TPM3 (tropomyosin) and CD9 (tetraspanin) are cytoskeletal/membrane proteins. UBL5 is a ubiquitin-like modifier. HNRNPC is an RNA-binding protein. CSNK2B (casein kinase 2β) regulates multiple stress pathways. OST4 is an oligosaccharyltransferase subunit. The module combines oxidative stress response, proteasomal activity, and cytoskeletal elements, all enriched in pre_tuft. The significant negative delta_inflammation_UC suggests this program is lost during UC inflammation.
Genes
Most correlated modules
- Mitochondrial Proteostasis · correlation 0.97
- Mitochondrial OxPhos/TCA · correlation 0.96
- Sulfur Redox Detox · correlation 0.96
- Pre-tuft Metabolic Identity · correlation 0.95
- Nucleolar RNA Processing · correlation 0.94
- Respiratory Chain Complex I · correlation 0.93
- Intestinal Progenitor Differentiation · correlation 0.92
- OxPhos Pre-tuft · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.