OxPhos Pre-tuft
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include CHCHD2 (mitochondrial coiled-coil-helix protein, Complex I assembly), ATP5MG (ATP synthase membrane subunit g), COX5B (cytochrome c oxidase subunit Vb, Complex IV), and UQCR10 (ubiquinol-cytochrome c reductase subunit, Complex III) — four core OxPhos components. PFN1 (profilin-1) links to actin dynamics, GSTP1 to glutathione-mediated oxidative stress defense, EDF1 to transcriptional coactivation, and FXYD3 to ion transport. POLR2L is a shared RNA Pol II subunit. All genes enriched in pre_tuft. The module is suppressed in inflammation and restored by treatment. The OxPhos theme is clear with supporting cytoskeletal and stress-defense genes.
Genes
Most correlated modules
- Mitochondrial Proteostasis · correlation 0.97
- Nucleolar RNA Processing · correlation 0.96
- Electron Transport Chain · correlation 0.95
- Pre-tuft Metabolic Identity · correlation 0.95
- Respiratory Chain Complex I · correlation 0.94
- Oxidative Stress Response · correlation 0.92
- Sulfur Redox Detox · correlation 0.91
- Mitochondrial OxPhos/TCA · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.