Mitochondrial Proteostasis
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include COX8A (Complex IV), NDUFB10 (Complex I), TOMM7 (mitochondrial outer membrane translocase), and GADD45GIP1 (mitochondrial matrix protein), alongside PFDN5 (prefoldin chaperone), HSBP1 (heat shock binding protein), and PRDX2 (peroxiredoxin antioxidant). The module combines mitochondrial protein import and respiratory chain components with proteostasis/chaperone machinery. All genes are strongly enriched in pre_tuft cells. The module is suppressed in inflammation and restored by treatment, consistent with a pre_tuft metabolic identity program. DYNLL1 and SRI add cytoskeletal/calcium-binding context but the dominant theme is mitochondrial biogenesis and proteostasis.
Genes
Most correlated modules
- Pre-tuft Metabolic Identity · correlation 0.98
- Respiratory Chain Complex I · correlation 0.98
- Sulfur Redox Detox · correlation 0.97
- Oxidative Stress Response · correlation 0.97
- OxPhos Pre-tuft · correlation 0.97
- Nucleolar RNA Processing · correlation 0.96
- Mitochondrial OxPhos/TCA · correlation 0.96
- Intestinal Progenitor Differentiation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.