AADAC — Arylacetamide deacetylase
AADAC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AADAC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Gluconeogenesis/fructose metabolism Nutrient metabolism | ADIRF, ENTPD5, FBP1, HEBP1, KHK, PCK2, PEPD, PGRMC2 +2 more | View in SCUBA |
About the gene
| Synonyms | CES5A1, DAC |
|---|---|
| Chromosome | 3: 151814073-151828488 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.