ADIRF — Adipogenesis regulatory factor
ADIRF belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADIRF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Gluconeogenesis/fructose metabolism Nutrient metabolism | AADAC, ENTPD5, FBP1, HEBP1, KHK, PCK2, PEPD, PGRMC2 +2 more | View in SCUBA |
| Fibroblasts | Quiescent Anti-inflammatory Fibroblast Developmental | CHCHD10, DACH1, FXYD6, IGFBP3, KHDRBS3, LSP1, NDRG2, PDE1A +3 more | View in SCUBA |
| Lymphatic endothelial | Leukotriene Biosynthesis Lipid metabolism | AKAP12, APOLD1, EMP1, ITM2A, LTC4S, PLAC9, SNCG, THBD | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | CLMN, FRMD3, GPX3, HIGD1B, KLHL23, MAP3K20, PLCE1, TINAGL1 | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ARPC1A, BCAM, CCDC3, CRIP1, EFHD1, GPRC5C, GPX3, HRC +10 more | View in SCUBA |
About the gene
| Synonyms | AFRO, APM2, C10orf116 |
|---|---|
| Chromosome | 10: 86968432-86983934 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.