Gluconeogenesis/fructose metabolism
Gene co-expression module in Enterocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PCK2, FBP1 and KHK drive gluconeogenesis and fructose metabolism, a hallmark of mature absorptive colonocytes. PEPD, AADAC, PTGR1, ENTPD5 and HEBP1 add broader metabolic and detoxification functions. The module is core-coherent and uniformly expressed across subsets, consistent with a differentiated enterocyte metabolic state rather than contamination.
Genes
AADAC, ADIRF, ENTPD5, FBP1, HEBP1, KHK, PCK2, PEPD, PGRMC2, PTGR1, REEP6
Most correlated modules
- Brush-border nutrient uptake · correlation 0.95
- Lipid/bile acid uptake · correlation 0.94
- Colonocyte Solute Transport · correlation 0.91
- PGC1A/ERRG metabolic program · correlation 0.90
- Carbohydrate Digestion/Detox · correlation 0.88
- Chylomicron lipid absorption · correlation 0.88
- Microvillus actin cytoskeleton · correlation 0.86
- Enterocyte lipid metabolism · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.