ENTPD5 — Ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
ENTPD5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENTPD5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Gluconeogenesis/fructose metabolism Nutrient metabolism | AADAC, ADIRF, FBP1, HEBP1, KHK, PCK2, PEPD, PGRMC2 +2 more | View in SCUBA |
| Goblet cells | Colonocyte Differentiation Program Epithelial development | ASCL2, CAMK1D, CDK6, EDIL3, FOXN3, HMGCS2, IRF2BP2, KLF5 +8 more | View in SCUBA |
About the gene
| Synonyms | CD39L4, NTPDase-5, PCPH |
|---|---|
| Chromosome | 14: 73958010-74019399 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP- glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.