FBP1 — Fructose-bisphosphatase 1
FBP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Gluconeogenesis/fructose metabolism Nutrient metabolism | AADAC, ADIRF, ENTPD5, HEBP1, KHK, PCK2, PEPD, PGRMC2 +2 more | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FGR, FN1, GCHFR +19 more | View in SCUBA |
About the gene
| Synonyms | FBP |
|---|---|
| Chromosome | 9: 94603133-94640249 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Hydrolase |
| Biological process | Carbohydrate metabolism, Gluconeogenesis |
Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.