PCK2 — Phosphoenolpyruvate carboxykinase 2, mitochondrial
PCK2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Gluconeogenesis/fructose metabolism Nutrient metabolism | AADAC, ADIRF, ENTPD5, FBP1, HEBP1, KHK, PEPD, PGRMC2 +2 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE +20 more | View in SCUBA |
About the gene
| Synonyms | PEPCK, PEPCK2 |
|---|---|
| Chromosome | 14: 24094053-24110598 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Decarboxylase, Lyase |
| Biological process | Gluconeogenesis |
Function
Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Can play an active role in glyceroneogenesis and gluconeogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.