ACACA — Acetyl-CoA carboxylase alpha
ACACA belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACACA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt CFTR secretion Secretion | CFTR, DACH1, EIF4G3, EML4, HNMT, MBOAT1, PLCE1, SULT1E1 +1 more | View in SCUBA |
About the gene
| Synonyms | ACAC, Acac1, ACACalpha, ACC, ACC-alpha, ACC1, ACCA, ACCalpha, hACC1 |
|---|---|
| Chromosome | 17: 37084992-37406836 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Ligase, Multifunctional enzyme |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.