PLCE1 — Phospholipase C epsilon 1
PLCE1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLCE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt CFTR secretion Secretion | ACACA, CFTR, DACH1, EIF4G3, EML4, HNMT, MBOAT1, SULT1E1 +1 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | ADIRF, CLMN, FRMD3, GPX3, HIGD1B, KLHL23, MAP3K20, TINAGL1 | View in SCUBA |
| Smooth muscle cells | Pericyte Signature Development | AC100803.3, CCND1, COX4I2, CPM, ENTPD3, GPR20, GPRIN3, GRIP2 +8 more | View in SCUBA |
About the gene
| Synonyms | KIAA1516, NPHS3, PLCE |
|---|---|
| Chromosome | 10: 93993931-94332823 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Guanine-nucleotide releasing factor, Hydrolase, Transducer |
| Biological process | Lipid degradation, Lipid metabolism |
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.