EIF4G3 — Eukaryotic translation initiation factor 4 gamma 3
EIF4G3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF4G3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Actomyosin signaling migration & adhesion | ACIN1, CYBC1, GALNT1, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH, PTPRA +8 more | View in SCUBA |
| Enterocytes | Crypt CFTR secretion Secretion | ACACA, CFTR, DACH1, EML4, HNMT, MBOAT1, PLCE1, SULT1E1 +1 more | View in SCUBA |
| Lymphatic endothelial | Focal Adhesion Migration migration & adhesion | BIRC6, CDC42BPA, DOCK1, GNAQ, LPP, NF1, PAM, PTK2 +2 more | View in SCUBA |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | APC, ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EPB41 +21 more |
About the gene
| Synonyms | eIF4GII |
|---|---|
| Chromosome | 1: 20806292-21177285 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor, RNA-binding |
| Biological process | Protein biosynthesis, Translation regulation |
Function
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Functional homolog of EIF4G1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.