DACH1 — Dachshund family transcription factor 1

DACH1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DACH1's module in each cell type

Cell type	Module	Shares the module with
Enterocytes	Crypt CFTR secretion Secretion	ACACA, CFTR, EIF4G3, EML4, HNMT, MBOAT1, PLCE1, SULT1E1 +1 more	View in SCUBA
Fibroblasts	Quiescent Anti-inflammatory Fibroblast Developmental	ADIRF, CHCHD10, FXYD6, IGFBP3, KHDRBS3, LSP1, NDRG2, PDE1A +3 more	View in SCUBA
Neutrophils	Neutrophil Differentiation Developmental	DGKD, FAR1, MPP7, MSRA, PAM, PLCL2, PTBP2, RELL1 +1 more
Pericytes	Pericyte ECM Secretion ECM production	ATP1A2, CPM, CSRP2, EFEMP1, FRZB, GULP1, MASP1, NDUFAF4 +3 more	View in SCUBA

About the gene

Synonyms	DACH
Chromosome	13: 71437966-71867204
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.