EML4 — EMAP like 4

EML4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EML4's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Interferon Response Anti-viral	ACAP1, ARHGAP15, BCL2, CD44, CD46, DSE, FCGR2B, GATAD1 +7 more	View in SCUBA
CD4⁺ T cells	Integrin Adhesion Migration migration & adhesion	ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1 +11 more	View in SCUBA
Enterocytes	Crypt CFTR secretion Secretion	ACACA, CFTR, DACH1, EIF4G3, HNMT, MBOAT1, PLCE1, SULT1E1 +1 more	View in SCUBA
Gamma-delta T cells	IFN-gamma Receptor Signaling Inflammation	BORCS5, CCDC93, CDC42SE2, DHCR7, IFNGR1, PDE4B, PGRMC2, PLEKHA2 +3 more
Innate lymphoid cells	IFN-driven ILC1 Activation Inflammation	AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3 +21 more	View in SCUBA
Mucosal-associated invariant T cell	RUNX3 Tissue Identity T cell maturation	B4GALT1, CD44, CDK17, CHD1, CYLD, EP300, GPBP1, KMT2E +10 more
Natural Killer cells	Circadian Apoptotic Priming Stress	BBC3, CORO7, CTDP1, LDB2, NR1D2, OFD1, RNF125, SERPINE2 +1 more	View in SCUBA

About the gene

Synonyms	C2orf2, ELP120, ROPP120
Chromosome	2: 42169353-42332548
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Biological process	Cell cycle, Cell division, Mitosis

Function

Essential for the formation and stability of microtubules (MTs). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.