CD226 — CD226 molecule
CD226 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD226's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD52, DENND3, EVL, IDH2, IL17RE, IL23R +13 more | View in SCUBA |
| Gamma-delta T cells | γδ T Cell Identity T cell maturation | AGAP1, AGPAT4, C1orf21, CD47, GAS7, ITGA5, ITGAM, MYO1G +7 more | |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CLDND1, CTNNBL1 +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Activation Signaling TCR Signaling | ARFGEF1, ARIH1, CARD11, CCDC88C, GLS, KANSL1, KMT5B, MAP3K2 +12 more | |
| Natural Killer cells | NK Cell Activation activation | AHNAK, AKT3, ANXA1, C16orf54, C1orf162, CD300A, ITGAX, PLAC8 +2 more | View in SCUBA |
About the gene
| Synonyms | DNAM-1, DNAM1, PTA1, TLiSA1 |
|---|---|
| Chromosome | 18: 69831158-69961803 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Cell adhesion |
Function
Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus- infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.