AHRR — Aryl hydrocarbon receptor repressor
AHRR belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AHRR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1, CTNNBL1 +27 more | View in SCUBA |
About the gene
| Synonyms | AHH, AHHR, bHLHe77, KIAA1234 |
|---|---|
| Chromosome | 5: 321714-438291 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.