NRF2 Oxidative Stress
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 36 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 36 genes have a known function matching the annotation |
Why this annotation
Hub genes include SLC7A11 (xCT, cystine/glutamate antiporter, key NRF2 target and ferroptosis resistance gene, extremely high mono_mac enrichment at 23.8x), GCLM (glutamate-cysteine ligase modifier subunit, rate-limiting enzyme in glutathione synthesis, NRF2 target), CYP1B1 (cytochrome P450 1B1, oxidative metabolism, NRF2/AhR target, 20.6x mono_mac), NQO2 (quinone oxidoreductase, oxidative stress protection), SPHK1 (sphingosine kinase 1, lipid signaling/survival), IL1R1 (IL-1 receptor, inflammatory), IL3RA (IL-3 receptor alpha), SMOX (spermine oxidase, polyamine catabolism generating H2O2), STK17A (DRAK2, stress-activated kinase). SLC7A11+GCLM+NQO2+CYP1B1 form a coherent NRF2-driven oxidative stress/ferroptosis resistance program. This is the strongest and most interpretable module in the batch.
Genes
ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1, CTNNBL1, CTSL, CYP1B1, GCLM, GPAT3, HMOX1, IL1R1, IL3RA, LPXN, MAP3K20, METTL9, NAB2, NBPF19, NQO2, RALA, RNF24, SERINC2, SLC26A11, SLC44A1, SLC7A11, SMIM3, SMOX, SPHK1, STK17A, TFPI, TIMP1, TMEM38B, TXNRD1
Most correlated modules
- Osmotic Stress Response · correlation 0.89
- Lipid-Sensing Transcriptional · correlation 0.85
- MMP-driven ECM Remodeling · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.