ADH1B — Alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADH1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Quiescent Stromal Identity Developmental | CXCL12, FXYD1, GSN, GSTM5, METTL7A, NFIA, PLAC9, SELENOP +1 more | View in SCUBA |
| Smooth muscle cells | Telocyte/Fibroblast Contamination Cell contamination | ABI3BP, ASB2, BCHE, BMP4, C5orf66-AS1, CDCA7L, FENDRR, HPSE2 +5 more | View in SCUBA |
About the gene
| Synonyms | ADH2 |
|---|---|
| Chromosome | 4: 99304971-99352760 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyze the NADH-dependent reduction of all-trans- retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.