FXYD1 — FXYD domain containing ion transport regulator 1
FXYD1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FXYD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Quiescent Stromal Identity Developmental | ADH1B, CXCL12, GSN, GSTM5, METTL7A, NFIA, PLAC9, SELENOP +1 more | View in SCUBA |
| Glial cells | Enteric Glial Identity Activation | FAM181B, FIBIN, HTRA1, METTL7A, MRPS6, NDRG2, NKAIN3, PLEKHB1 +1 more | View in SCUBA |
| Smooth muscle cells | Oxidative Muscle Metabolism Mitochondrial & OxPhos | CAV2, COX7A1, CRIP2, HCFC1R1, LGR6, MFGE8, MGST3, NDUFB7 +2 more | View in SCUBA |
About the gene
| Synonyms | PLM |
|---|---|
| Chromosome | 19: 35138824-35143109 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.