Quiescent Stromal Identity
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes CXCL12, ADH1B, SPARCL1, SELENOP, GSN, and NFIA define a quiescent stromal fibroblast identity program. CXCL12 is a hallmark of niche-forming stromal fibroblasts; ADH1B marks retinoid-metabolizing stromal cells; SPARCL1 is a matricellular protein enriched in quiescent stroma; SELENOP reflects antioxidant homeostasis. The module is significantly downregulated in UC inflammation and restored in remission, consistent with a homeostatic stromal identity lost during active disease.
Genes
ADH1B, CXCL12, FXYD1, GSN, GSTM5, METTL7A, NFIA, PLAC9, SELENOP, SPARCL1
Most correlated modules
- Subepithelial Fibroblast Identity · correlation 0.91
- Microfibril ECM Fibroblast · correlation 0.89
- Elastin-Fibronectin ECM · correlation 0.84
- Elastic Fiber ECM · correlation 0.82
- Wnt-niche Fibroblast · correlation 0.75
- Subepithelial Fibroblast · correlation 0.73
- OSR1+ Deep Fibroblast · correlation 0.71
- BMP-antagonizing Fibroblast · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.