AKAP10 — A-kinase anchoring protein 10
AKAP10 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKAP10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Post-transcriptional Regulation Housekeeping | ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2, CEP350 +34 more | View in SCUBA |
About the gene
| Synonyms | D-AKAP2, MGC9414, PRKA10 |
|---|---|
| Chromosome | 17: 19904302-19978343 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G- alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.