Post-transcriptional Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 43 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 43 genes have a known function matching the annotation |
Why this annotation
Hub genes TNRC6A and TNRC6B encode GW182 paralogs that are core components of the RISC/miRNA silencing complex. HELZ is an RNA helicase involved in mRNA decay and translational regulation. MBNL1, CELF2, and RBM6 are established RNA splicing and post-transcriptional regulators. PHC3 is a Polycomb repressor component involved in transcriptional silencing. The module broadly reflects post-transcriptional gene regulation including miRNA-mediated silencing and alternative splicing. All genes show weak membership and coherence is unknown, indicating a loosely co-regulated program. The mild enrichment in mono_mac for a subset of genes (RREB1, BLTP1, BRWD1, ATRN) is consistent with macrophage identity rather than contamination.
Genes
AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2, CEP350, CNOT6L, GLS, HELZ, HERC4, IKBKB, ITSN2, KIAA0319L, MBNL1, MIGA1, MLXIP, MYCBP2, PDS5A, PHACTR4, PHC3, PHKB, PIK3C2A, PKN2, POGZ, POU2F1, QKI, R3HDM2, RBM6, RREB1, RYK, SENP6, SIRT1, SLC4A7, SNX13, TNRC6A, TNRC6B, TTC17, UBE4B, VPS13C, ZNF148
Most correlated modules
- Chromatin Remodeling · correlation 0.97
- Chromatin Regulatory Genes · correlation 0.97
- Myeloid Receptor Signaling · correlation 0.96
- DNA Damage Response · correlation 0.96
- Epigenetic Remodeling · correlation 0.96
- Sphingolipid Membrane Homeostasis · correlation 0.96
- Endosomal Vesicle Trafficking · correlation 0.95
- Rho GTPase Signaling · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.