BAZ2B — Bromodomain adjacent to zinc finger domain 2B
BAZ2B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAZ2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh program B cell help | CCDC50, CDK5R1, CXCR5, IL6R, LY96, MTUS1, PASK, PIP4P2 +10 more | View in SCUBA |
| Enterocytes | Focal adhesion actin Migration & adhesion | CARMIL1, COP1, FRYL, KIF13A, LPP, MYO6, PALLD, PTK2 +4 more | View in SCUBA |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | BPTF, GTF2I, INSR, MYO10, PDZD8, RERE, TOP2B, ZKSCAN1 | View in SCUBA |
| Hematopoietic progenitor cells | T/NK Cell Identity Lymphcyte development | ATM, CD53, LCP1, LGMN, MED13L, NKG7, PREX1, RASSF2 +3 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | CHD9, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PHKB, PLXDC2 +4 more | View in SCUBA |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BLTP1, BRWD1, CELF2, CEP350 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | C1RL, CD2AP, GIT2, KIF5B, MIA2, RIF1, SPAG9, SUPT16H +1 more |
About the gene
| Synonyms | WALp4 |
|---|---|
| Chromosome | 2: 159318979-159616569 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex. Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.