ALAS1 — 5'-aminolevulinate synthase 1
ALAS1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ALAS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | AP-1 Inflammatory Stress Inflammatory | ATP13A3, BATF3, CCDC71L, DDX21, FOSL1, NINJ1, PANX1, SBNO2 +1 more | View in SCUBA |
| Monocytes | Co-chaperone Proteostasis Stress | AHSA1, BAG3, CACYBP, FBXL14, FKBP4, HSPA6, HSPB1, SERPINH1 +2 more | View in SCUBA |
About the gene
| Synonyms | ALAS, ALAS-H, ALAS3 |
|---|---|
| Chromosome | 3: 52198086-52214327 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Heme biosynthesis |
Function
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.