AP-1 Inflammatory Stress
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
BATF3 is a stress-responsive AP-1/bZIP transcription factor involved in inflammatory gene regulation. FOSL1 (Fra-1) is an AP-1 component induced by inflammatory and stress signals. SBNO2 is a transcriptional repressor downstream of IL-10/anti-inflammatory signaling but also induced in inflammation. PANX1 encodes Pannexin-1, a channel involved in ATP release and inflammasome activation. ALAS1 is the rate-limiting enzyme in heme biosynthesis, induced by metabolic/stress signals. NINJ1 mediates plasma membrane rupture during cell death/pyroptosis. DDX21 is an RNA helicase involved in ribosome biogenesis and stress responses. ATP13A3 is a polyamine transporter induced under stress. SPSB1 is a SOCS-box protein involved in cytokine signaling. The module is upregulated in UC and CD inflammation. The AP-1 factors (BATF3, FOSL1), PANX1, and NINJ1 suggest an inflammatory cell death/stress-signaling program in fibroblasts, neighboring M117 and M10 which are also inflammation-associated stress modules.
Genes
ALAS1, ATP13A3, BATF3, CCDC71L, DDX21, FOSL1, NINJ1, PANX1, SBNO2, SPSB1
Most correlated modules
- ER Stress UPR · correlation 0.91
- Inflammatory Fibroblast Activation · correlation 0.89
- Hypoxia Response · correlation 0.88
- Hypoxia Metabolic Stress · correlation 0.87
- NF-κB Stress Response · correlation 0.84
- NFAT-cAMP Signaling · correlation 0.83
- Inflammatory ECM Remodeling · correlation 0.74
- Inflammatory Fibroblast Activation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.