TNF Apoptosis Resistance
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes include CFLAR (anti-apoptotic FLIP protein), TNFRSF1A (TNF receptor 1), CASP10 (apoptosis caspase), MXD1 (stress-responsive MYC antagonist), RHOF (Rho GTPase), TRIM31 (E3 ubiquitin ligase), and CEACAM6 (inflammation marker). The module is strongly upregulated in UC inflammation and downregulated in remission, with enrichment in sen_colono and inf_colono subsets. CFLAR/TNFRSF1A/CASP10 together indicate TNF-driven apoptosis signaling with survival resistance. MXD1 and DHRS9 add stress/differentiation context. This represents a TNF receptor-mediated apoptosis resistance program in inflamed colonocytes.
Genes
Most correlated modules
- IFN-γ Metabolic Reprogramming · correlation 0.97
- Epithelial Junction Integrity · correlation 0.94
- Senescent Cell Death · correlation 0.93
- Senescent Surface Identity · correlation 0.93
- Junction Cytoskeletal Remodeling · correlation 0.92
- Senescent Stress Signaling · correlation 0.91
- Senescent Colonocyte Differentiation · correlation 0.91
- Type I Interferon Response · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.