GK — Glycerol kinase
GK belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA stability regulation Immune regulation | APLP2, ARID5B, CARHSP1, GLCCI1, GRAMD4, HIVEP1, METTL8, MPG +12 more | View in SCUBA |
| Enterocytes | Brush-border enterocyte Absorption | CD2AP, CEACAM20, ERBIN, HHLA2, MAN1A1, MAPK6, NCKAP5, SLC36A1 | View in SCUBA |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Monocytes | TNF-driven Activation Inflammatory | ATP13A3, CD44, DCUN1D3, DSE, IVNS1ABP, LAMB3, LITAF, POMP +3 more | View in SCUBA |
| Neutrophils | Neutrophil Adhesion Signaling Migration & adhesion | B3GNT5, ETS2, ICAM1, LCP2, PDE4B, SKIL, ZNF267 |
About the gene
| Synonyms | GK1, GKD |
|---|---|
| Chromosome | X: 30653359-30731462 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Glycerol metabolism |
Function
Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn- glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.