BATF3 — Basic leucine zipper ATF-like transcription factor 3
BATF3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BATF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | AP-1 Inflammatory Stress Inflammatory | ALAS1, ATP13A3, CCDC71L, DDX21, FOSL1, NINJ1, PANX1, SBNO2 +1 more | View in SCUBA |
| Monocytes | Inflammasome Activation Innate immunity | AIM2, APOBEC3G, ARID5B, BST2, CASP5, CD47, CNDP2, CYSTM1 +4 more | View in SCUBA |
| Pericytes | Pericyte Inflammatory Activation Inflammatory | CRISPLD2, FILIP1L, KCNJ8, MARCKS, PAG1, PDGFA, RHOBTB3, RHOQ +3 more | View in SCUBA |
| Smooth muscle cells | XBP1 UPR Response Protein processing & ER | ADAMTS10, AKAP13, ATP1A1, BNIP3L, CHRD, DLC1, HERPUD1, MICAL1 +5 more | View in SCUBA |
About the gene
| Synonyms | JDP1, JUNDM1, SNFT |
|---|---|
| Chromosome | 1: 212686417-212699840 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross- present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.