AMDHD2 — Amidohydrolase domain containing 2
AMDHD2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AMDHD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT, CTSS +35 more | View in SCUBA |
About the gene
| Synonyms | CGI-14 |
|---|---|
| Chromosome | 16: 2520357-2531422 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Carbohydrate metabolism |
Function
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.