Lysosomal Hydrolase Program
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 44 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 44 genes have a known function matching the annotation |
Why this annotation
HEXA (lysosomal hexosaminidase A), GUSB (lysosomal beta-glucuronidase), CTSZ (cathepsin Z), PSAP (prosaposin, activator of lysosomal sphingolipid hydrolases), DPP7 (lysosomal dipeptidyl peptidase), SUMF2 (sulfatase-modifying factor), GRN (granulin, lysosomal protease regulator), SYNGR2 (synaptogyrin-2, lysosomal membrane), MTMR14 (phosphoinositide phosphatase at lysosomes) define a strong lysosomal hydrolase/degradation program. HVCN1 and CYBC1 support phagocyte oxidase function. This is a canonical macrophage lysosomal/phagolysosomal degradation module.
Genes
AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT, CTSS, CTSZ, CYBC1, DAP3, DPP7, EPN1, FES, FEZ2, GAA, GRN, GUSB, HCK, HEXA, HVCN1, LIMA1, MOSPD2, MR1, MTMR14, NAGLU, PLBD1, PLD3, PSAP, RENBP, SIRT2, SLC22A18, SLC66A2, SMAP1, SNAP23, SUMF2, SYNGR2, TMBIM6, TMEM86A, TNFRSF14, TOP1, VPS51, VSIR
Most correlated modules
- Retromer Endosomal Sorting · correlation 0.94
- ER Protein Quality Control · correlation 0.94
- Macrophage Proliferation · correlation 0.90
- Innate Antiviral Sensing · correlation 0.90
- Endosomal Membrane Trafficking · correlation 0.90
- ER Stress UPR · correlation 0.89
- Translation Initiation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.