ARPIN — Actin related protein 2/3 complex inhibitor
ARPIN belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARPIN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARSA, CD81, CLDN7, CLEC2B, COMT, CTSS +35 more | View in SCUBA |
About the gene
| Synonyms | C15orf38, MGC61550 |
|---|---|
| Chromosome | 15: 89895006-89912952 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.